RECOVERY FROM ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE LEWIS RAT
نویسندگان
چکیده
منابع مشابه
The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat.
Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant. The histological studies showed demyelination in the lumbar, sacral and coccygeal dorsal and ventral spinal roots and to a lesser extent in the spinal cord, including the dorsa...
متن کاملThe pathophysiology of acute experimental allergic encephalomyelitis induced by whole spinal cord in the Lewis rat.
Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig spinal cord and Freund's adjuvants, in order to determine the cause of the neurological signs. These studies demonstrated demyelination-induced nerve conduction block in the large and also the smaller diameter fibres at the ve...
متن کاملDemyelination and Nerve Conduction Abnormalities in Acute and Chronic Experimental Allergic Encephalomyelitis in the Lewis Rat
We have been using histological and electrophysiological techniques to compare the pathology and pathophysiology in different forms of experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE induced by sensitization to myelin basic protein (MBP) or by the passive transfer of MBPspecific lymphocytes, there is inflammation and demyelination in the ventral and dorsal spinal ro...
متن کاملInvolvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat. A histological and electrophysiological study.
Histological and electrophysiological studies were performed in Lewis rats with acute experimental allergic encephalomyelitis (EAE) in order to determine the extent of dorsal root ganglion (DRG) involvement. Histological studies showed inflammation and demyelination in both the central nervous system (CNS) and peripheral nervous system (PNS). The DRG was the most affected region of the PNS and ...
متن کاملRecovery from acute experimental allergic encephalomyelitis in the Lewis rat. Early restoration of nerve conduction and repair by Schwann cells and oligodendrocytes.
Light and electron microscopic histological studies and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by whole spinal cord or myelin basic protein to determine the mechanism of clinical recovery. In these animals, total clinical recovery from complete paraplegia may occur as early as 4 days after the onset of hindlimb ...
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ژورنال
عنوان ژورنال: Brain
سال: 1989
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/112.2.393